Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Otx2  orthodenticle homeobox 2   (Synonyms: E130306E05Rik)
Results	Reference
1	J:320518 Belle M, Parray A, Belle M, Chedotal A, Nguyen-Ba-Charvet KT, PlexinA2 and Sema6A are required for retinal progenitor cell migration. Dev Growth Differ. 2016 Jun;58(5):492-502
1	J:156665 Brzezinski JA 4th, Lamba DA, Reh TA, Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb;137(4):619-29
1	J:277122 Buenaventura DF, Corseri A, Emerson MM, Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):2787-2799
1*	J:60735 Bumsted KM, Barnstable CJ, Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. Invest Ophthalmol Vis Sci. 2000 Mar;41(3):903-8
1	J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502
1	J:160729 Das G, Choi Y, Sicinski P, Levine EM, Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells. Neural Dev. 2009;4:15
1	J:251433 Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW, The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017 Apr 11;19(2):351-363
1*	J:176607 Kameda Y, Saitoh T, Fujimura T, Hes1 regulates the number and anterior-posterior patterning of mesencephalic dopaminergic neurons at the mid/hindbrain boundary (isthmus). Dev Biol. 2011 Oct 1;358(1):91-101
1	J:193195 Katoh K, Yamazaki R, Onishi A, Sanuki R, Furukawa T, G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70
1	J:208421 Klimova L, Kozmik Z, Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
1	J:130851 Lavado A, Lagutin OV, Oliver G, Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development. 2008 Feb;135(3):441-50
1	J:327070 Li Q, Han Z, Singh N, Terre B, Fame RM, Arif U, Page TD, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov HGW, Surendran K, Wu L, Virga JQ, Zhao YT, Schuller U, Wechsler-Reya RJ, Lehtinen MK, Roy S, Liu Z, Stracker TH, Zhao H, Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development. Cell Death Differ. 2022 Aug;29(8):1596-1610
1	J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079
1*	J:35538 Mallamaci A, Di Blas E, Briata P, Boncinelli E, Corte G, OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area. Mech Dev. 1996 Aug;58(1-2):165-78
1	J:253963 Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW, Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development. Dev Cell. 2018 Jan 8;44(1):13-28.e3
1*	J:175980 Mortensen AH, MacDonald JW, Ghosh D, Camper SA, Candidate genes for panhypopituitarism identified by gene expression profiling. Physiol Genomics. 2011 Oct 6;43(19):1105-16
1	J:218295 Mortensen AH, Schade V, Lamonerie T, Camper SA, Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
1	J:177908 Muranishi Y, Terada K, Inoue T, Katoh K, Tsujii T, Sanuki R, Kurokawa D, Aizawa S, Tamaki Y, Furukawa T, An Essential Role for RAX Homeoprotein and NOTCH-HES Signaling in Otx2 Expression in Embryonic Retinal Photoreceptor Cell Fate Determination. J Neurosci. 2011 Nov 16;31(46):16792-807
1	J:78037 Muzio L, DiBenedetto B, Stoykova A, Boncinelli E, Gruss P, Mallamaci A, Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice. Nat Neurosci. 2002 Aug;5(8):737-45
1	J:98698 Muzio L, Mallamaci A, Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium. J Neurosci. 2005 Apr 27;25(17):4435-41
1*	J:102092 Muzio L, Mallamaci A, Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb Cortex. 2003 Jun;13(6):641-7
1	J:330186 Nguyen H, Sokpor G, Parichha A, Pham L, Saikhedkar N, Xie Y, Ulmke PA, Rosenbusch J, Pirouz M, Behr R, Stoykova A, Brand-Saberi B, Nguyen HP, Staiger JF, Tole S, Tuoc T, BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain. Front Cell Dev Biol. 2022;10:1011109
1	J:160263 Nielsen CM, Dymecki SM, Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol. 2010 Apr 15;340(2):430-7
1	J:181398 Ogata-Iwao M, Inatani M, Iwao K, Takihara Y, Nakaishi-Fukuchi Y, Irie F, Sato S, Furukawa T, Yamaguchi Y, Tanihara H, Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6671-9
1	J:339856 Ovadia S, Cui G, Elkon R, Cohen-Gulkar M, Zuk-Bar N, Tuoc T, Jing N, Ashery-Padan R, SWI/SNF complexes are required for retinal pigmented epithelium differentiation and for the inhibition of cell proliferation and neural differentiation programs. Development. 2023 Aug 15;150(16)
1	J:320719 Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben-Reuven L, Olender T, Taketo MM, Radosevic V, Bobic-Rasonja M, Trnski S, Holtzman MJ, Jovanov-Milosevic N, Reiner O, Tole S, Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nat Commun. 2022 Feb 2;13(1):633
1	J:321252 Pereira Luppi M, Azcorra M, Caronia-Brown G, Poulin JF, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC, Ramakrishnan C, Fenno L, Kim YS, Deisseroth K, Cicchetti F, Dombeck DA, Awatramani R, Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins. Cell Rep. 2021 Nov 9;37(6):109975
1	J:245876 Rohacek AM, Bebee TW, Tilton RK, Radens CM, McDermott-Roe C, Peart N, Kaur M, Zaykaner M, Cieply B, Musunuru K, Barash Y, Germiller JA, Krantz ID, Carstens RP, Epstein DJ, ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
1	J:318245 Son EJ, Ma JH, Ankamreddy H, Shin JO, Choi JY, Wu DK, Bok J, Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3746-51
1	J:157924 Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ, COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar;137(5):725-34
1	J:302296 Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, Hui JHL, Jiang L, Kwan KM, SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2009568118
1	J:314218 Wang J, Liu Y, Su Z, Pan L, Lu F, Qu J, Hou L, The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium. Curr Eye Res. 2017 Nov;42(11):1537-1544
1	J:326670 Witteveen JS, Loopstok SR, Ballesteros LL, Boonstra A, van Bakel NHM, van Boekel WHP, Martens GJM, Visser JE, Kolk SM, HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch-Nyhan disease. Cell Mol Life Sci. 2022 Jun 4;79(6):341
1	J:223223 Wu Q, Fukuda K, Weinstein M, Graff JM, Saga Y, SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. Development. 2015 Feb 1;142(3):575-86
1	J:247847 Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin X, Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. FASEB J. 2017 Aug;31(8):3349-3358